Michigan State Spartans - NCAAF Schedule for 2021
| Date | Opponent | Game | Result | Score | ATS | Spread | OU | Total |
|---|---|---|---|---|---|---|---|---|
| Sep 3, 2021 | @ Northwestern | REG | W | 38-21 | W | +3 | O | 45.5 |
| Sep 11, 2021 | vs Youngstown State | REG | W | 42-14 | P | -28 | O | 52 |
| Sep 18, 2021 | @ Miami-FL | REG | W | 38-17 | W | +7 | U | 57.5 |
| Sep 25, 2021 | vs Nebraska | REG | W | 23-20 | L | -3.5 | U | 55 |
| Oct 2, 2021 | vs Western Kentucky | REG | W | 48-31 | W | -10.5 | O | 66.5 |
| Oct 9, 2021 | @ Rutgers | REG | W | 31-13 | W | -4 | U | 49.5 |
| Oct 16, 2021 | @ Indiana | REG | W | 20-15 | W | -3.5 | U | 48.5 |
| Oct 30, 2021 | vs Michigan | REG | W | 37-33 | W | +4 | O | 50.5 |
| Nov 6, 2021 | @ Purdue | REG | L | 40-29 | L | -2.5 | O | 53.5 |
| Nov 13, 2021 | vs Maryland | REG | W | 40-21 | W | -11.5 | O | 60.5 |
| Nov 20, 2021 | @ Ohio State | REG | L | 56-7 | L | +19.5 | U | 70.5 |
| Nov 27, 2021 | vs Penn State | REG | W | 30-27 | W | +3.5 | O | 51.5 |
| Dec 30, 2021 | vs Pittsburgh | PST | W | 31-21 | W | -3.5 | U | 55 |
