SMU Mustangs - NCAAF Schedule for 2021
| Date | Opponent | Game | Result | Score | ATS | Spread | OU | Total |
|---|---|---|---|---|---|---|---|---|
| Sep 4, 2021 | vs Abilene Christian | REG | W | 56-9 | W | -32 | U | 66 |
| Sep 11, 2021 | vs North Texas | REG | W | 35-12 | W | -22.5 | U | 75 |
| Sep 18, 2021 | @ Louisiana Tech | REG | W | 39-37 | L | -11 | O | 65.5 |
| Sep 25, 2021 | @ Texas Christian | REG | W | 42-34 | W | +9.5 | O | 65.5 |
| Oct 2, 2021 | vs South Florida | REG | W | 41-17 | W | -21 | U | 68.5 |
| Oct 9, 2021 | @ Navy | REG | W | 31-24 | L | -13.5 | U | 57 |
| Oct 21, 2021 | vs Tulane | REG | W | 55-26 | W | -14 | O | 70.5 |
| Oct 30, 2021 | @ Houston | REG | L | 44-37 | L | -1 | O | 61.5 |
| Nov 6, 2021 | @ Memphis | REG | L | 28-25 | L | -3.5 | U | 72.5 |
| Nov 13, 2021 | vs Central Florida | REG | W | 55-28 | W | -7 | O | 61.5 |
| Nov 20, 2021 | @ Cincinnati | REG | L | 48-14 | L | +9.5 | U | 65.5 |
| Nov 27, 2021 | vs Tulsa | REG | L | 34-31 | L | -6.5 | O | 62.5 |
