Clemson Tigers - NCAAF Schedule for 2021
| Date | Opponent | Game | Result | Score | ATS | Spread | OU | Total |
|---|---|---|---|---|---|---|---|---|
| Sep 4, 2021 | vs Georgia | REG | L | 10-3 | L | -3 | U | 51.5 |
| Sep 11, 2021 | vs South Carolina State | REG | W | 49-3 | L | -50.5 | U | 56 |
| Sep 18, 2021 | vs Georgia Tech | REG | W | 14-8 | L | -27.5 | U | 52.5 |
| Sep 25, 2021 | @ North Carolina State | REG | L | 27-21 | L | -10.5 | O | 47.5 |
| Oct 2, 2021 | vs Boston College | REG | W | 19-13 | L | -14.5 | U | 46.5 |
| Oct 15, 2021 | @ Syracuse | REG | W | 17-14 | L | -13.5 | U | 44 |
| Oct 23, 2021 | @ Pittsburgh | REG | L | 27-17 | L | +3.5 | U | 47 |
| Oct 30, 2021 | vs Florida State | REG | W | 30-20 | W | -9.5 | O | 47.5 |
| Nov 6, 2021 | @ Louisville | REG | W | 30-24 | W | -3.5 | O | 46.5 |
| Nov 13, 2021 | vs Connecticut | REG | W | 44-7 | L | -40.5 | O | 50.5 |
| Nov 20, 2021 | vs Wake Forest | REG | W | 48-27 | W | -3.5 | O | 57 |
| Nov 27, 2021 | @ South Carolina | REG | W | 30-0 | W | -11.5 | U | 42.5 |
| Dec 29, 2021 | @ Iowa State | PST | W | 20-13 | W | -2 | U | 45 |
