Louisville Cardinals - NCAAF Schedule for 2021
| Date | Opponent | Game | Result | Score | ATS | Spread | OU | Total |
|---|---|---|---|---|---|---|---|---|
| Sep 6, 2021 | @ Mississippi | REG | L | 43-24 | L | +9 | U | 74 |
| Sep 11, 2021 | vs Eastern Kentucky | REG | W | 30-3 | L | -30 | U | 62.5 |
| Sep 17, 2021 | vs Central Florida | REG | W | 42-35 | W | +7 | O | 67.5 |
| Sep 25, 2021 | @ Florida State | REG | W | 31-23 | W | +1 | U | 61 |
| Oct 2, 2021 | @ Wake Forest | REG | L | 37-34 | W | +7 | O | 64.5 |
| Oct 9, 2021 | vs Virginia | REG | L | 34-33 | L | -2.5 | U | 69.5 |
| Oct 23, 2021 | vs Boston College | REG | W | 28-14 | W | -4 | U | 57.5 |
| Oct 30, 2021 | @ North Carolina State | REG | L | 28-13 | L | +6 | U | 57 |
| Nov 6, 2021 | vs Clemson | REG | L | 30-24 | L | +3.5 | O | 46.5 |
| Nov 13, 2021 | vs Syracuse | REG | W | 41-3 | W | -3 | U | 55.5 |
| Nov 18, 2021 | @ Duke | REG | W | 62-22 | W | -20 | O | 60.5 |
| Nov 27, 2021 | vs Kentucky | REG | L | 52-21 | L | -3 | O | 57.5 |
| Dec 28, 2021 | vs Air Force | PST | L | 31-28 | L | +1 | O | 55 |
