Louisville Cardinals - NCAAF Schedule for 2022
| Date | Opponent | Game | Result | Score | ATS | Spread | OU | Total |
|---|---|---|---|---|---|---|---|---|
| Sep 3, 2022 | @ Syracuse | REG | L | 31-7 | L | -5.5 | U | 55.5 |
| Sep 9, 2022 | @ Central Florida | REG | W | 20-14 | W | +5.5 | U | 62.5 |
| Sep 16, 2022 | vs Florida State | REG | L | 35-31 | L | +2.5 | O | 57 |
| Sep 24, 2022 | vs South Florida | REG | W | 41-3 | W | -15.5 | U | 63.5 |
| Oct 1, 2022 | @ Boston College | REG | L | 34-33 | L | -13.5 | O | 48 |
| Oct 8, 2022 | @ Virginia | REG | W | 34-17 | W | +1.5 | O | 47.5 |
| Oct 22, 2022 | vs Pittsburgh | REG | W | 24-10 | W | -1.5 | U | 55 |
| Oct 29, 2022 | vs Wake Forest | REG | W | 48-21 | W | +3 | O | 66.5 |
| Nov 5, 2022 | vs James Madison | REG | W | 34-10 | W | -6.5 | U | 53.5 |
| Nov 12, 2022 | @ Clemson | REG | L | 31-16 | L | +7 | U | 52 |
| Nov 19, 2022 | vs North Carolina State | REG | W | 25-10 | W | -4 | U | 43 |
| Nov 26, 2022 | @ Kentucky | REG | L | 26-13 | L | +3.5 | U | 42.5 |
| Dec 17, 2022 | vs Cincinnati | PST | W | 24-7 | W | -2.5 | U | 38.5 |
