Indiana Hoosiers - NCAAF Schedule for 2021
| Date | Opponent | Game | Result | Score | ATS | Spread | OU | Total |
|---|---|---|---|---|---|---|---|---|
| Sep 4, 2021 | @ Iowa | REG | L | 34-6 | L | +3.5 | U | 46 |
| Sep 11, 2021 | vs Idaho | REG | W | 56-14 | W | -31.5 | O | 53.5 |
| Sep 18, 2021 | vs Cincinnati | REG | L | 38-24 | L | +4 | O | 50 |
| Sep 25, 2021 | @ Western Kentucky | REG | W | 33-31 | L | -9.5 | O | 62.5 |
| Oct 2, 2021 | @ Penn State | REG | L | 24-0 | L | +12.5 | U | 54 |
| Oct 16, 2021 | vs Michigan State | REG | L | 20-15 | L | +3.5 | U | 48.5 |
| Oct 23, 2021 | vs Ohio State | REG | L | 54-7 | L | +21 | O | 59 |
| Oct 30, 2021 | @ Maryland | REG | L | 38-35 | W | +3.5 | O | 48 |
| Nov 6, 2021 | @ Michigan | REG | L | 29-7 | L | +20.5 | U | 51 |
| Nov 13, 2021 | vs Rutgers | REG | L | 38-3 | L | -6.5 | U | 42.5 |
| Nov 20, 2021 | vs Minnesota | REG | L | 35-14 | L | +7.5 | O | 43 |
| Nov 27, 2021 | @ Purdue | REG | L | 44-7 | L | +17.5 | O | 50.5 |
