Louisiana-Lafayette Ragin' Cajuns - NCAAF Schedule for 2021
| Date | Opponent | Game | Result | Score | ATS | Spread | OU | Total |
|---|---|---|---|---|---|---|---|---|
| Sep 4, 2021 | @ Texas | REG | L | 38-18 | L | +8.5 | U | 58 |
| Sep 11, 2021 | vs Nicholls State | REG | W | 27-24 | L | -26 | U | 65 |
| Sep 16, 2021 | vs Ohio | REG | W | 49-14 | W | -19 | O | 56.5 |
| Sep 25, 2021 | @ Georgia Southern | REG | W | 28-20 | L | -14.5 | U | 54.5 |
| Oct 2, 2021 | @ South Alabama | REG | W | 20-18 | L | -12 | U | 53 |
| Oct 12, 2021 | vs Appalachian State | REG | W | 41-13 | W | +4.5 | U | 57.5 |
| Oct 21, 2021 | @ Arkansas State | REG | W | 28-27 | L | -18 | U | 70 |
| Oct 30, 2021 | vs Texas State | REG | W | 45-0 | W | -21 | U | 58 |
| Nov 4, 2021 | vs Georgia State | REG | W | 21-17 | L | -13.5 | U | 53.5 |
| Nov 13, 2021 | @ Troy | REG | W | 35-21 | W | -6.5 | O | 48 |
| Nov 20, 2021 | @ Liberty | REG | W | 42-14 | W | +4 | O | 53.5 |
| Nov 27, 2021 | vs Louisiana-Monroe | REG | W | 21-16 | L | -21.5 | U | 55.5 |
| Dec 4, 2021 | vs Appalachian State | REG | W | 24-16 | W | +2.5 | U | 52 |
| Dec 18, 2021 | @ Marshall | PST | W | 36-21 | W | -4 | O | 56 |
