Vanderbilt Commodores - NCAAF Schedule for 2021
| Date | Opponent | Game | Result | Score | ATS | Spread | OU | Total |
|---|---|---|---|---|---|---|---|---|
| Sep 4, 2021 | vs East Tennessee State | REG | L | 23-3 | L | -21 | U | 45 |
| Sep 11, 2021 | @ Colorado State | REG | W | 24-21 | W | +6.5 | U | 52 |
| Sep 18, 2021 | vs Stanford | REG | L | 41-23 | L | +13 | O | 49 |
| Sep 25, 2021 | vs Georgia | REG | L | 62-0 | L | +36 | O | 54.5 |
| Oct 2, 2021 | vs Connecticut | REG | W | 30-28 | L | -14.5 | O | 51.5 |
| Oct 9, 2021 | @ Florida | REG | L | 42-0 | L | +39 | U | 60 |
| Oct 16, 2021 | @ South Carolina | REG | L | 21-20 | W | +19 | U | 50 |
| Oct 23, 2021 | vs Mississippi State | REG | L | 45-6 | L | +20.5 | U | 53 |
| Oct 30, 2021 | vs Missouri | REG | L | 37-28 | W | +16 | O | 62.5 |
| Nov 13, 2021 | vs Kentucky | REG | L | 34-17 | W | +21.5 | U | 52.5 |
| Nov 20, 2021 | @ Mississippi | REG | L | 31-17 | W | +35.5 | U | 65.5 |
| Nov 27, 2021 | @ Tennessee | REG | L | 45-21 | W | +32 | O | 64.5 |
