Ohio State Buckeyes - NCAAF Schedule for 2021
| Date | Opponent | Game | Result | Score | ATS | Spread | OU | Total |
|---|---|---|---|---|---|---|---|---|
| Sep 2, 2021 | @ Minnesota | REG | W | 45-31 | P | -14 | O | 62 |
| Sep 11, 2021 | vs Oregon | REG | L | 35-28 | L | -14.5 | U | 64.5 |
| Sep 18, 2021 | vs Tulsa | REG | W | 41-20 | L | -24.5 | O | 60.5 |
| Sep 25, 2021 | vs Akron | REG | W | 59-7 | W | -48.5 | U | 66.5 |
| Oct 2, 2021 | @ Rutgers | REG | W | 52-13 | W | -15 | O | 58 |
| Oct 9, 2021 | vs Maryland | REG | W | 66-17 | W | -21.5 | O | 71.5 |
| Oct 23, 2021 | @ Indiana | REG | W | 54-7 | W | -21 | O | 59 |
| Oct 30, 2021 | vs Penn State | REG | W | 33-24 | L | -18.5 | U | 60.5 |
| Nov 6, 2021 | @ Nebraska | REG | W | 26-17 | L | -14 | U | 67.5 |
| Nov 13, 2021 | vs Purdue | REG | W | 59-31 | W | -19 | O | 65.5 |
| Nov 20, 2021 | vs Michigan State | REG | W | 56-7 | W | -19.5 | U | 70.5 |
| Nov 27, 2021 | @ Michigan | REG | L | 42-27 | L | -6.5 | O | 64.5 |
| Jan 1, 2022 | vs Utah | PST | W | 48-45 | L | -4 | O | 64.5 |
