Southern Miss Golden Eagles - NCAAF Schedule for 2021
| Date | Opponent | Game | Result | Score | ATS | Spread | OU | Total |
|---|---|---|---|---|---|---|---|---|
| Sep 4, 2021 | @ South Alabama | REG | L | 31-7 | L | +2 | U | 56.5 |
| Sep 11, 2021 | vs Grambling State | REG | W | 37-0 | W | -23 | U | 47.5 |
| Sep 18, 2021 | vs Troy | REG | L | 21-9 | L | +11 | U | 49.5 |
| Sep 25, 2021 | @ Alabama | REG | L | 63-14 | L | +45 | O | 58 |
| Oct 2, 2021 | @ Rice | REG | L | 24-19 | L | +1 | U | 45 |
| Oct 9, 2021 | vs Texas El Paso | REG | L | 26-13 | L | +1.5 | U | 46.5 |
| Oct 16, 2021 | vs Alabama-Birmingham | REG | L | 34-0 | L | +17 | U | 43.5 |
| Oct 30, 2021 | @ Middle Tennessee | REG | L | 35-10 | L | +12.5 | U | 47 |
| Nov 6, 2021 | vs North Texas | REG | L | 38-14 | L | +5.5 | O | 49 |
| Nov 13, 2021 | @ Texas-San Antonio | REG | L | 27-17 | W | +32.5 | U | 54.5 |
| Nov 19, 2021 | @ Louisiana Tech | REG | W | 35-19 | W | +15.5 | O | 47.5 |
| Nov 27, 2021 | vs Florida International | REG | W | 37-17 | W | -14.5 | O | 46 |
