Arizona Cardinals - NFL Schedule for 2021
| Date | Opponent | Game | Result | Score | ATS | Spread | OU | Total |
|---|---|---|---|---|---|---|---|---|
| Aug 13, 2021 | vs Dallas | PRE | W | 19-16 | W | -2 | U | 37.5 |
| Aug 20, 2021 | vs Kansas City | PRE | L | 17-10 | L | +3.5 | U | 41 |
| Sep 12, 2021 | @ Tennessee | REG | W | 38-13 | W | +2.5 | U | 54 |
| Sep 19, 2021 | vs Minnesota | REG | W | 34-33 | L | -3.5 | O | 51 |
| Sep 26, 2021 | @ Jacksonville | REG | W | 31-19 | W | -8 | U | 51.5 |
| Oct 3, 2021 | @ LA Rams | REG | W | 37-20 | W | +4 | O | 54 |
| Oct 10, 2021 | vs San Francisco | REG | W | 17-10 | W | -6 | U | 48.5 |
| Oct 17, 2021 | @ Cleveland | REG | W | 37-14 | W | +3 | O | 48 |
| Oct 24, 2021 | vs Houston | REG | W | 31-5 | W | -20 | U | 47.5 |
| Oct 28, 2021 | vs Green Bay | REG | L | 24-21 | L | -6.5 | U | 50.5 |
| Nov 7, 2021 | @ San Francisco | REG | W | 31-17 | W | +5.5 | O | 44.5 |
| Nov 14, 2021 | vs Carolina | REG | L | 34-10 | L | -7 | O | 41.5 |
| Nov 21, 2021 | @ Seattle | REG | W | 23-13 | W | +5.5 | U | 45 |
| Dec 5, 2021 | @ Chicago | REG | W | 33-22 | W | -8 | O | 43 |
| Dec 13, 2021 | vs LA Rams | REG | L | 30-23 | L | -3 | O | 51 |
| Dec 19, 2021 | @ Detroit | REG | L | 30-12 | L | -13 | U | 48 |
| Dec 25, 2021 | vs Indianapolis | REG | L | 22-16 | L | -3 | U | 48 |
| Jan 2, 2022 | @ Dallas | REG | W | 25-22 | W | +6.5 | U | 53 |
| Jan 9, 2022 | vs Seattle | REG | L | 38-30 | L | -5.5 | O | 48.5 |
| Jan 17, 2022 | @ LA Rams | PST | L | 34-11 | L | +3.5 | U | 49 |
