Detroit Lions - NFL Schedule for 2021
| Date | Opponent | Game | Result | Score | ATS | Spread | OU | Total |
|---|---|---|---|---|---|---|---|---|
| Aug 13, 2021 | vs Buffalo | PRE | L | 16-15 | L | -2 | U | 36.5 |
| Aug 21, 2021 | @ Pittsburgh | PRE | L | 26-20 | W | +7 | O | 36.5 |
| Aug 27, 2021 | vs Indianapolis | PRE | L | 27-17 | L | +1.5 | O | 33.5 |
| Sep 12, 2021 | vs San Francisco | REG | L | 41-33 | W | +9.5 | O | 46 |
| Sep 20, 2021 | @ Green Bay | REG | L | 35-17 | L | +11.5 | O | 49.5 |
| Sep 26, 2021 | vs Baltimore | REG | L | 19-17 | W | +7.5 | U | 51 |
| Oct 3, 2021 | @ Chicago | REG | L | 24-14 | L | +3 | U | 41.5 |
| Oct 10, 2021 | @ Minnesota | REG | L | 19-17 | W | +10 | U | 49.5 |
| Oct 17, 2021 | vs Cincinnati | REG | L | 34-11 | L | +3.5 | U | 46.5 |
| Oct 24, 2021 | @ LA Rams | REG | L | 28-19 | W | +16.5 | U | 50.5 |
| Oct 31, 2021 | vs Philadelphia | REG | L | 44-6 | L | +3 | O | 48 |
| Nov 14, 2021 | @ Pittsburgh | REG | T | 16-16 | W | +6 | U | 40.5 |
| Nov 21, 2021 | @ Cleveland | REG | L | 13-10 | W | +13.5 | U | 42.5 |
| Nov 25, 2021 | vs Chicago | REG | L | 16-14 | W | +2.5 | U | 41.5 |
| Dec 5, 2021 | vs Minnesota | REG | W | 29-27 | W | +7 | O | 47.5 |
| Dec 12, 2021 | @ Denver | REG | L | 38-10 | L | +12.5 | O | 42 |
| Dec 19, 2021 | vs Arizona | REG | W | 30-12 | W | +13 | U | 48 |
| Dec 26, 2021 | @ Atlanta | REG | L | 20-16 | W | +7.5 | U | 43 |
| Jan 2, 2022 | @ Seattle | REG | L | 51-29 | L | +9 | O | 41 |
| Jan 9, 2022 | vs Green Bay | REG | W | 37-30 | W | +4 | O | 45 |
