Buffalo Bills - NFL Schedule for 2021
| Date | Opponent | Game | Result | Score | ATS | Spread | OU | Total |
|---|---|---|---|---|---|---|---|---|
| Aug 13, 2021 | @ Detroit | PRE | W | 16-15 | W | +2 | U | 36.5 |
| Aug 21, 2021 | @ Chicago | PRE | W | 41-15 | W | +4 | O | 37 |
| Aug 28, 2021 | vs Green Bay | PRE | W | 19-0 | W | -7.5 | U | 37.5 |
| Sep 12, 2021 | vs Pittsburgh | REG | L | 23-16 | L | -6.5 | U | 48 |
| Sep 19, 2021 | @ Miami | REG | W | 35-0 | W | -3.5 | U | 48 |
| Sep 26, 2021 | vs Washington | REG | W | 43-21 | W | -7 | O | 45.5 |
| Oct 3, 2021 | vs Houston | REG | W | 40-0 | W | -18.5 | U | 47.5 |
| Oct 10, 2021 | @ Kansas City | REG | W | 38-20 | W | +3 | O | 57 |
| Oct 18, 2021 | @ Tennessee | REG | L | 34-31 | L | -6 | O | 53.5 |
| Oct 31, 2021 | vs Miami | REG | W | 26-11 | P | -15 | U | 48.5 |
| Nov 7, 2021 | @ Jacksonville | REG | L | 9-6 | L | -14.5 | U | 48.5 |
| Nov 14, 2021 | @ NY Jets | REG | W | 45-17 | W | -13.5 | O | 48.5 |
| Nov 21, 2021 | vs Indianapolis | REG | L | 41-15 | L | -7 | O | 49.5 |
| Nov 25, 2021 | @ New Orleans | REG | W | 31-6 | W | -7 | U | 45 |
| Dec 6, 2021 | vs New England | REG | L | 14-10 | L | -3 | U | 40 |
| Dec 12, 2021 | @ Tampa Bay | REG | L | 33-27 | L | +3.5 | O | 53 |
| Dec 19, 2021 | vs Carolina | REG | W | 31-14 | W | -14.5 | O | 43 |
| Dec 26, 2021 | @ New England | REG | W | 33-21 | W | +1 | O | 43.5 |
| Jan 2, 2022 | vs Atlanta | REG | W | 29-15 | P | -14 | U | 46 |
| Jan 9, 2022 | vs NY Jets | REG | W | 27-10 | W | -16 | U | 43 |
| Jan 15, 2022 | vs New England | PST | W | 47-17 | W | -4.5 | O | 43 |
| Jan 23, 2022 | @ Kansas City | PST | L | 42-36 | L | +2.5 | O | 54 |
