Indianapolis Colts - NFL Schedule for 2021
| Date | Opponent | Game | Result | Score | ATS | Spread | OU | Total |
|---|---|---|---|---|---|---|---|---|
| Aug 15, 2021 | vs Carolina | PRE | W | 21-18 | P | -3 | O | 33 |
| Aug 21, 2021 | @ Minnesota | PRE | W | 12-10 | W | +2 | U | 37 |
| Aug 27, 2021 | @ Detroit | PRE | W | 27-17 | W | -1.5 | O | 33.5 |
| Sep 12, 2021 | vs Seattle | REG | L | 28-16 | L | +3 | U | 49 |
| Sep 19, 2021 | vs LA Rams | REG | L | 27-24 | W | +4 | O | 48 |
| Sep 26, 2021 | @ Tennessee | REG | L | 25-16 | L | +4.5 | U | 47 |
| Oct 3, 2021 | @ Miami | REG | W | 27-17 | W | +2.5 | O | 42 |
| Oct 11, 2021 | @ Baltimore | REG | L | 31-25 | W | +7.5 | O | 46.5 |
| Oct 17, 2021 | vs Houston | REG | W | 31-3 | W | -11.5 | U | 45 |
| Oct 24, 2021 | @ San Francisco | REG | W | 30-18 | W | +3.5 | O | 41.5 |
| Oct 31, 2021 | vs Tennessee | REG | L | 34-31 | L | -3 | O | 51 |
| Nov 4, 2021 | vs NY Jets | REG | W | 45-30 | W | -10 | O | 45.5 |
| Nov 14, 2021 | vs Jacksonville | REG | W | 23-17 | L | -10.5 | U | 48 |
| Nov 21, 2021 | @ Buffalo | REG | W | 41-15 | W | +7 | O | 49.5 |
| Nov 28, 2021 | vs Tampa Bay | REG | L | 38-31 | L | +3 | O | 53 |
| Dec 5, 2021 | @ Houston | REG | W | 31-0 | W | -10 | U | 45.5 |
| Dec 18, 2021 | vs New England | REG | W | 27-17 | W | -1 | U | 46.5 |
| Dec 25, 2021 | @ Arizona | REG | W | 22-16 | W | +3 | U | 48 |
| Jan 2, 2022 | vs Las Vegas | REG | L | 23-20 | L | -8.5 | U | 46.5 |
| Jan 9, 2022 | @ Jacksonville | REG | L | 26-11 | L | -14 | U | 43.5 |
