Jacksonville Jaguars - NFL Schedule for 2021
| Date | Opponent | Game | Result | Score | ATS | Spread | OU | Total |
|---|---|---|---|---|---|---|---|---|
| Aug 14, 2021 | vs Cleveland | PRE | L | 23-13 | L | -4 | U | 37 |
| Aug 23, 2021 | @ New Orleans | PRE | L | 23-21 | W | +4 | O | 40 |
| Aug 29, 2021 | @ Dallas | PRE | W | 34-14 | W | -4 | O | 36 |
| Sep 12, 2021 | @ Houston | REG | L | 37-21 | L | -3.5 | O | 45.5 |
| Sep 19, 2021 | vs Denver | REG | L | 23-13 | L | +6 | U | 45 |
| Sep 26, 2021 | vs Arizona | REG | L | 31-19 | L | +8 | U | 51.5 |
| Sep 30, 2021 | @ Cincinnati | REG | L | 24-21 | W | +7.5 | U | 46 |
| Oct 10, 2021 | vs Tennessee | REG | L | 37-19 | L | +4.5 | O | 48.5 |
| Oct 17, 2021 | vs Miami | REG | W | 23-20 | W | +1.5 | U | 47 |
| Oct 31, 2021 | @ Seattle | REG | L | 31-7 | L | +4 | U | 44.5 |
| Nov 7, 2021 | vs Buffalo | REG | W | 9-6 | W | +14.5 | U | 48.5 |
| Nov 14, 2021 | @ Indianapolis | REG | L | 23-17 | W | +10.5 | U | 48 |
| Nov 21, 2021 | vs San Francisco | REG | L | 30-10 | L | +6.5 | U | 45.5 |
| Nov 28, 2021 | vs Atlanta | REG | L | 21-14 | L | +1.5 | U | 46 |
| Dec 5, 2021 | @ LA Rams | REG | L | 37-7 | L | +14 | U | 48 |
| Dec 12, 2021 | @ Tennessee | REG | L | 20-0 | L | +8.5 | U | 44.5 |
| Dec 19, 2021 | vs Houston | REG | L | 30-16 | L | -6 | O | 40 |
| Dec 26, 2021 | @ NY Jets | REG | L | 26-21 | L | +2.5 | O | 43 |
| Jan 2, 2022 | @ New England | REG | L | 50-10 | L | +17 | O | 41.5 |
| Jan 9, 2022 | vs Indianapolis | REG | W | 26-11 | W | +14 | U | 43.5 |
