Ohio State vs Penn State Picks & Odds: Buckeyes Have Dominated In October

The Ohio State Buckeyes (7-0 SU, 4-2-1 ATS) are 12-0 SU and 10-1-1 ATS in their last 12 games played in October heading into this weekend’s Big Ten showdown against the Penn State Nittany Lions (6-1, 4-3). The Buckeyes will try to remain undefeated this season by cashing in as an Ohio State vs Penn State prediction this Saturday in Happy Valley.

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Ohio State vs Penn State Sportsbook Odds

The Buckeyes opened as 14.5-point road favorites before betting action on them moved the Ohio State vs Penn State odds up to Ohio State -15.5. The total in this Big Ten rivalry game has also moved up to 61.5 points after Sportsbook at 60.5 points. The UNDER is 5-2 in the last seven games between the Buckeyes and the Nittany Lions.

Get the best Ohio State vs Penn State odds and lines available from our recommended sportsbooks for your favorite picks of the night.

Ohio State Hasn’t Been Tested Since Week 1

The Buckeyes rolled to another easy win on Saturday, crushing the Iowa Hawkeyes 54-10 as 10-point favorites. Since Sportsbook its season with an underwhelming 21-10 win at home against the Notre Dame Fighting Irish, Ohio State has averaged 54.3 points per game over its last six outings and has beaten opponents by an average of 38.7 points per game during that stretch.

C.J. Stroud went 20-for-30 for 286 passing yards with four touchdowns and an interception in the blowout win over Iowa. Stroud has emerged as the favorite to win the Heisman Trophy this season with 2,023 passing yards, 28 passing touchdowns and only four interceptions through his first seven games in 2022. The junior quarterback’s strong play has helped lead the team to a 5-0 SU and 4-0-1 ATS record over the Buckeyes’ last five games. 

Penn State Looked Sharp In Win Over Minnesota 

The Nittany Lions had a five-game winning streak snapped and fell to 0-3 ATS over their last three games with their 41-17 loss as 7-point road underdogs against the Michigan Wolverines in Week 7. Penn State bounced back with a 45-17 win as a 5.5-point favorite at home against the Minnesota Golden Gophers on Saturday. Sean Clifford had his best game of the season, going 23-for-31 with 295 passing yards, four touchdown passes and one interception.

Penn State is well on its way to its best season since going 11-2 SU back in 2019. But if the Nittany Lions hope to take a real step forward in 2022, they’ll need to generate better efforts as an underdog than they did against the Wolverines. The Nittany Lions are 0-5 SU and 1-4 ATS in their last five games as an underdog.

Ohio State: Keys to Win

The Buckeyes haven’t won a game by less than 11 points this season and have won their last six games by over 30 points. As long as C.J. Stroud and this solid Buckeyes defense continue to play at this level on Saturday, a win and cover on the road as an Ohio State vs Penn State prediction is well within reach.

Penn State: Keys to Win

The Nittany Lions rank 20th in the nation in scoring defense, allowing 18.9 points per game, but that defense struggled in the loss to Michigan. Keeping up with the high-powered Buckeyes in a shootout isn’t a realistic path to victory, so it will be up to Penn State’s defense to at least slow Ohio State down enough to cover the spread or win as an Ohio State vs Penn State pick.

College Football Computer Pick: Penn State +15.5

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