James Harden and the 76ers are big home favorites Wednesday in Knicks vs 76ers odds.

Knicks vs 76ers Prediction & Odds: Philly Looks To Sweep 2-Game Set vs New York

The Philadelphia 76ers (37-23 SU, 31-29 ATS) will look to keep rolling when they host the New York Knicks (25-36, 26-35) at Wells Fargo Center in the second half of a home-and-home. The Sixers enter the matchup on a three-game win streak while the Knicks have lost five straight. Can Philadelphia cover the spread as a big favorite in Wednesday’s matchup? Find out in our Knicks vs 76ers prediction.

Knicks vs 76ers Betting Preview
  • Date/Time: March 2, 7:30 p.m. ET
  • Arena: Wells Fargo Center
  • TV Coverage: ESPN, NBC Sports Philadelphia, MSG
  • Sportsbook Knicks vs 76ers Odds: 76ers -10.5 | O/U 224
  • Knicks vs 76ers Betting Matchup Report

Knicks vs 76ers Odds & Analysis

Sportsbook Odds

Philadelphia comes into this one as a big favorite, Sportsbook at -10.5 on the moneyline. The total was set at 224 points with the OVER going 6-1 in New York’s last seven games and 4-1 in Philadelphia’s last five outings. The Sixers have enjoyed plenty of success against the Knicks in recent meetings, owning a record of 8-2 over the last 10 matchups – an important factor to consider when weighing your Knicks vs 76ers prediction.

Get the best Knicks vs 76ers odds and lines available from our recommended sportsbooks for your favorite picks of the night.

  • Best Spread
    -101
    -111
    NY+10.5
    -10.5PHI
  • Best Moneyline
    +475
    -544
    NY
    PHI
  • Best Total
    - -
    -110
    Over
    224Under

Knicks Lose 5th Straight In 1st Game Of Home-And-Home

The Knicks fell 125-109 on Sunday to the 76ers in their first meeting of the two-game set. RJ Barrett and Evan Fournier scored 24 points each to lead the team while Julius Randle added 16 points and 10 boards for a double-double.

New York simply hasn’t had enough firepower this season, ranking 27th in the NBA in scoring at 105 points per game. With a record of 1-9 over their last 10 contests, things aren’t getting any better for the Knicks, who seem to have more or less accepted their fate as a bottom-10 team through the home stretch of the season.

Derrick Rose (ankle), Nerlens Noel (foot), Kemba Walker (knee) and Quentin Grimes (knee) are out for Wednesday’s contest.

Embiid, Harden Impress In Big Win Over New York

The 76ers won their third straight game on Sunday with the victory over the Knicks as Joel Embiid (37 points) led the charge. A rejuvenated James Harden dropped 29 points, 16 assists and 10 rebounds for a triple-double in his second game since joining Philadelphia, while Tyrese Maxey added 21 points in the win.

Everyone knows what Embiid is capable of, but the real question for the Sixers down the stretch is what they will get out of Harden, who was reportedly unhappy in Brooklyn. It’s still early but Harden has lived up to all the expectations so far, averaging 28 points, 14 assists and nine boards through two games with the 76ers.

Knicks vs 76ers Pick & Insights

Knicks: Keys To Cover

The Knicks weren’t able to contain the 76ers on Sunday, but their defense may be their only hope of keeping tonight’s game close. Despite their position in the standings, New York owns the eighth-best defense in the NBA, allowing just 107 points per game. If the Knicks can hold Philadelphia to around that number, they should be able to at least cover the spread.

76ers: Keys To Cover

Embiid and Harden have shown great chemistry already through two contests together, averaging a combined 63.5 points per game. Add in depth scoring from Maxey and Tobias Harris and it seems almost impossible to stop this new-look Sixers squad.

Odds Shark’s Computer Knicks vs 76ers Prediction: 76ers -10.5

Check out more of Odds Shark’s signature NBA and NCAAB computer picks, plus our favorite sportsbooks that serve basketball customers.

Shark Bites
  • Philadelphia is 9-1 SU in the last 10 meetings at home.
  • New York is 0-5 ATS in its last 5 games.
  • The UNDER is 7-3 in the last 10 meetings.

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