Wake Forest Demon Deacons - NCAAF Schedule for 2021
| Date | Opponent | Game | Result | Score | ATS | Spread | OU | Total |
|---|---|---|---|---|---|---|---|---|
| Sep 3, 2021 | vs Old Dominion | REG | W | 42-10 | L | -32.5 | U | 61.5 |
| Sep 11, 2021 | vs Norfolk State | REG | W | 41-16 | L | -43 | U | 58 |
| Sep 18, 2021 | vs Florida State | REG | W | 35-14 | W | -4.5 | U | 63 |
| Sep 24, 2021 | @ Virginia | REG | W | 37-17 | W | +3.5 | U | 70.5 |
| Oct 2, 2021 | vs Louisville | REG | W | 37-34 | L | -7 | O | 64.5 |
| Oct 9, 2021 | @ Syracuse | REG | W | 40-37 | L | -6 | O | 58.5 |
| Oct 23, 2021 | @ Army | REG | W | 70-56 | W | -3 | O | 54 |
| Oct 30, 2021 | vs Duke | REG | W | 45-7 | W | -16 | U | 71.5 |
| Nov 6, 2021 | @ North Carolina | REG | L | 58-55 | L | +2.5 | O | 78 |
| Nov 13, 2021 | vs North Carolina State | REG | W | 45-42 | W | -1 | O | 64.5 |
| Nov 20, 2021 | @ Clemson | REG | L | 48-27 | L | +3.5 | O | 57 |
| Nov 27, 2021 | @ Boston College | REG | W | 41-10 | W | -6.5 | U | 64 |
| Dec 4, 2021 | vs Pittsburgh | REG | L | 45-21 | L | +3.5 | U | 73.5 |
| Dec 31, 2021 | @ Rutgers | PST | W | 38-10 | W | -17 | U | 63 |
