Duke Blue Devils - NCAAF Schedule for 2021
| Date | Opponent | Game | Result | Score | ATS | Spread | OU | Total |
|---|---|---|---|---|---|---|---|---|
| Sep 3, 2021 | @ Charlotte | REG | L | 31-28 | L | -6.5 | U | 60 |
| Sep 10, 2021 | vs North Carolina A&T | REG | W | 45-17 | W | -22.5 | O | 56.5 |
| Sep 18, 2021 | vs Northwestern | REG | W | 30-23 | W | +2.5 | O | 50 |
| Sep 25, 2021 | vs Kansas | REG | W | 52-33 | W | -16.5 | O | 57.5 |
| Oct 2, 2021 | @ North Carolina | REG | L | 38-7 | L | +19.5 | U | 73.5 |
| Oct 9, 2021 | vs Georgia Tech | REG | L | 31-27 | W | +4.5 | U | 60.5 |
| Oct 16, 2021 | @ Virginia | REG | L | 48-0 | L | +10.5 | U | 69.5 |
| Oct 30, 2021 | @ Wake Forest | REG | L | 45-7 | L | +16 | U | 71.5 |
| Nov 6, 2021 | vs Pittsburgh | REG | L | 54-29 | L | +21 | O | 64.5 |
| Nov 13, 2021 | @ Virginia Tech | REG | L | 48-17 | L | +13 | O | 50.5 |
| Nov 18, 2021 | vs Louisville | REG | L | 62-22 | L | +20 | O | 60.5 |
| Nov 27, 2021 | vs Miami-FL | REG | L | 47-10 | L | +20.5 | U | 67 |
