Notre Dame Fighting Irish - NCAAF Schedule for 2021
| Date | Opponent | Game | Result | Score | ATS | Spread | OU | Total |
|---|---|---|---|---|---|---|---|---|
| Sep 5, 2021 | @ Florida State | REG | W | 41-38 | L | -7 | O | 53.5 |
| Sep 11, 2021 | vs Toledo | REG | W | 32-29 | L | -16.5 | O | 55.5 |
| Sep 18, 2021 | vs Purdue | REG | W | 27-13 | W | -7.5 | U | 58.5 |
| Sep 25, 2021 | @ Wisconsin | REG | W | 41-13 | W | +6 | O | 43.5 |
| Oct 2, 2021 | vs Cincinnati | REG | L | 24-13 | L | +2 | U | 50.5 |
| Oct 9, 2021 | @ Virginia Tech | REG | W | 32-29 | W | +1 | O | 47 |
| Oct 23, 2021 | vs Southern California | REG | W | 31-16 | W | -7.5 | U | 59.5 |
| Oct 30, 2021 | vs North Carolina | REG | W | 44-34 | W | -3.5 | O | 62.5 |
| Nov 6, 2021 | vs Navy | REG | W | 34-6 | W | -21 | U | 47.5 |
| Nov 13, 2021 | @ Virginia | REG | W | 28-3 | W | -9 | U | 62 |
| Nov 20, 2021 | vs Georgia Tech | REG | W | 55-0 | W | -18 | U | 58 |
| Nov 27, 2021 | @ Stanford | REG | W | 45-14 | W | -21 | O | 53 |
| Jan 1, 2022 | vs Oklahoma State | PST | L | 37-35 | L | +1 | O | 45 |
