Notre Dame Fighting Irish - NCAAF Schedule for 2022
| Date | Opponent | Game | Result | Score | ATS | Spread | OU | Total |
|---|---|---|---|---|---|---|---|---|
| Sep 3, 2022 | @ Ohio State | REG | L | 21-10 | W | +17 | U | 58.5 |
| Sep 10, 2022 | vs Marshall | REG | L | 26-21 | L | -20.5 | U | 48 |
| Sep 17, 2022 | vs California | REG | W | 24-17 | L | -13.5 | P | 41 |
| Sep 24, 2022 | @ North Carolina | REG | W | 45-32 | W | +2.5 | O | 55.5 |
| Oct 8, 2022 | vs Brigham Young | REG | W | 28-20 | W | -3.5 | U | 51.5 |
| Oct 15, 2022 | vs Stanford | REG | L | 16-14 | L | -16.5 | U | 53.5 |
| Oct 22, 2022 | vs Nevada-Las Vegas | REG | W | 44-21 | L | -26 | O | 46.5 |
| Oct 29, 2022 | @ Syracuse | REG | W | 41-24 | W | 0 | O | 48 |
| Nov 5, 2022 | vs Clemson | REG | W | 35-14 | W | +3.5 | O | 43.5 |
| Nov 12, 2022 | @ Navy | REG | W | 35-32 | L | -17 | O | 40.5 |
| Nov 19, 2022 | vs Boston College | REG | W | 44-0 | W | -20 | O | 42 |
| Nov 26, 2022 | @ Southern California | REG | L | 38-27 | L | +4.5 | O | 63 |
| Dec 30, 2022 | @ South Carolina | PST | W | 45-38 | W | -5 | O | 50.5 |
