Bills vs Dolphins Odds & Picks Week 2: Miami's Red Hot at Hard Rock

The Buffalo Bills head to Miami as 2.5-point underdogs in Week 2 of the NFL season. With the total set at 50.5 football fans can expect an explosive offensive contest at Hard Rock Stadium.

Dive into all the Bills vs Dolphins Week 2 odds and my best bets for Thursday Night Football below.

Bills vs Dolphins Odds Week 2

Buffalo Bills vs Miami Dolphins , Sept. 12, 8:15 pm ET

As of September 11 at FanDuel

Bills vs Dolphins Picks Week 2

Dolphins -2.5 (-115)

It's important to note, the Dolphins are 8-2 ATS in their last 10 AFC East contests, and 9-2 SU in their last 11 games at Hard Rock Stadium. Running back Raheem Mostert will miss this contest after injuring his chest last week and speedster De'Von Achane is a game-time decision with an ankle issue. That leaves journeyman Jeff Wilson and rookie Jaylen Wright could be in line for a heavy workload. Be aware this total has fallen from 50.5 down to 48.5 this week as bettors pile on the primetime unders NFL betting trend. 

Each of these teams came away with a win in Week 1. Buffalo overcame an early deficit at home against Arizona, while Miami kicked a last second field goal to defeat Jacksonville. Josh Allen is a one-man wrecking crew. He threw for two touchdowns and ran in two more to propel the Bills to victory versus a stout Cardinals team. On the other side, Miami's defense gave up 17 points in the first half before cracking down and holding the Jaguars scoreless across the final two periods.

Buffalo beat Miami at Hard Rock last year, led by standout performances from Jordan Poyer, Taylor Rapp, and Stefon Diggs - who are all no longer on the team. Allen may have been able to will his way to victory against the Cards, but the Dolphins are a different story. A healthy Jaylen Waddle makes Miami a different team. Adding veteran leadership and the production of Calais Campbell is also huge for Mike McDaniels' squad.

Miami went 6-2 ATS as home favorites last year and I like that trend to continue. Bet on the Dolphins to get the job done as favorites in Week 2.

Be sure to check out our NFL betting sites for all the best lines. 

Bills vs Dolphins Prop Pick

Josh Allen OVER 0.5 Interceptions -135

For all his talents, Josh Allen has become a massive risk taker away from Highmark Stadium. He's thrown an interception in seven straight road contests and I like that betting trend to continue on Thursday Night Football.

Allen is a throwback gunslinger. The Wyoming star rightly believes he can make any throw on the football field, and will take risks to fit the ball into tight windows.

But, the Dolphins know #17 well, and I like their exotic coverage looks under new coordinator Anthony Weaver to fool Allen at least once in Week 2.

Check out our NFL computer picks page for all our expert picks each and every week of the season!

Bills vs Dolphins Betting Trends