The top-seeded Detroit Lions do battle with the Buffalo Bills in NFL Week 15 action. Detroit has won 10 consecutive games for the first time since 1934 while the Bills are looking to get back in the win column after dropping a game of the year candidate to the Rams in Week 14.
Take a look at all the Bills vs Lions odds and my best bets.
Bills vs Lions Odds Week 15
Buffalo Bills vs Detroit Lions, December 15th, 4:25 pm ET
| Team | Spread | Moneyline | Total |
| Buffalo Bills | +2.5 (-110) | +120 | O 53.5 (-110) |
| Detroit Lions | -2.5 (-110) | -141 | U 53.5 (-110) |
Bills vs Lions Week 15 Picks
Over 53.5 (-110)
The Lions second-ranked defense by EPA puts their reputation on the line against Josh Allen and the high-flying Buffalo Bills in Week 15. Shutting down the Bills top-ranked offense by EPA will be a tall task for a defense with 13 players on injured reserve. Even with a gargantuan total of 53.5 points, the OVER is my favorite bet.
Detroit eked out a 34-31 win over Green Bay on Thursday Night Football, with Jared Goff and the offense looking nigh on unstoppable. Goff completed all 10 of his pass attempts in the fourth quarter, and Jahmyr Gibbs and David Montgomery did their thing on the ground to finish off the stingy Packers.
Meanwhile, Allen is fresh off of the first three passing touchdown, rushing touchdown game in NFL history. Incredibly, Allen accounted for 424 yards of total offense, was not sacked, did not turn over the football, and Buffalo lost the football game.
The betting trends point to the over on Sunday. Eight of Buffalo's games this season have gone over, and over has hit in nine of the Lions last 12 games against top-10 scoring defenses. Both offenses rank in the top four in EPA per play. Plus, this is a matchup between the top two teams in points per game in the NFL. I like MVP candidates Allen and Jared Goff to put on a show in what could be a Super Bowl preview in Week 15.
Bills vs Lions Week 15 Props
Sam Laporta Under 3.5 Receptions +125
The Bills have defended tight ends well this season, allowing just 4.9 receptions and 39 receiving yards per game to the position. Expect that to continue with linebacker Matt Milano back in the fold.
For as good as Laporta is, he's exceeded this prop in just two of his past eight games. Bet Laporta under 3.5 receptions with confidence.
Bills vs Lions Week 15 Betting Trends
- Buffalo is 6-2 ATS in their last 8 games
- Detroit is 15-5 ATS in their last 20 games
- Detroit is 5-0 SU in their last 5 games at home
- The Detroit Lions are 10-0 (100.0%) in their last 10 games as a favorite
