It's Los Angeles Chargers versus Arizona Cardinals in the second of the NFL's Week 7 Monday Night Football double header. Can Jim Harbaugh and Justin Herbert get the better of Kyler Murray and Jonathan Gannon in this classic west coast battle?
Look for all the Chargers vs Cardinals odds and our best bets for Monday Night Football, below.
Chargers vs Cardinals Odds Week 7
Los Angeles Chargers vs Arizona Cardinals, Oct. 21, 9:00 pm ET
| Team | Spread | Moneyline | Total |
| Los Angeles Chargers | -2.5 (-115) | -154 | O 43.5 (-110) |
| Arizona Cardinals | +2.5 (-105) | +130 | U 43.5 (-110) |
Chargers vs Cardinals Week 7 Picks
Chargers ML
The Chargers defense is a sneaky good unit, sitting second in EPA per play allowed this season. They've also generated nine total takeaways, while the offense has given up the ball just twice so far.
On offense, Los Angeles' ground and pound approach has generated nearly 130 rushing yards per game. However, they sit just 26th in points per game (18.2) and 28th in offensive yards per game (281.8).
Arizona has been slightly more explosive offensively, and rank 10th in yards per play (5.8). However, their defense has been a sieve, allowing 153 rushing yards per game, and sitting 27th in rushing success rate allowed (45.2%). The Cardinals are also dead last in opponent third down conversion percentage (49.25). That's a recipe for disaster against the conservative Chargers team that loves to run the football.
Los Angeles is 8-3 SU in their last 11 games as a favorite. I like Jim Harbaugh's run the football and stop the run approach to grind out the win for the Chargers. Especially if Marvin Harrison Jr. can't go.
Chargers vs Cardinals Week 7 Props
Daiyan Henley Under 7.5 Tackles & Assists (-110)
Chargers linebacker Daiyan Henley began losing snaps to rookie Junior Colson last week. Henley played just 42 snaps, or 76% of total Chargers defensive plays. While Colson found himself on the field for 58% of plays.
On top of that, Henley has exceeded his player prop line of 7.5 tackles and assists just twice in his past 19 contests. Add Henley under 7.5 tackles to your Chargers vs Cardinals Week 7 player prop card.
Chargers vs Cardinals Week 7 News
Both the Chargers and Cardinals are relatively healthy heading into this matchup. Joey Bosa is would be the biggest loss for the Chargers and he remains questionable. That being said, one major injury to keep an eye on is the status of Marvin Harrison Jr. The standout rookie left last week's game against Green Bay with a concussion and it remains to be seen if he will pass protocol in time for MNF.
Chargers vs Cardinals Week 7 Betting Trends
- The Los Angeles Chargers are 8-3 (72.7%) in their last 11 games as a favorite
- The under hit in 8 of the Los Angeles Chargers last 10 games on the road
- The Los Angeles Chargers are 8-3 (72.7%) against the spread in their last 11 games as a favorite
