| win | Derrick Lewis | 47 0 | 1 0 | | -175 +150 | FN May 11, 2024 | KO/TKO | 3 | :49 |
| loss | Derrick Lewis | 3 27 | 0 2 | 0 0 | +370 -485 | FN Nov 4, 2023 | DEC | 5 | 1:27 |
| win | Derrick Lewis | | | | +175 -205 | UFC 291 Jul 29, 2023 | KO/TKO | 1 | :33 |
| loss | Derrick Lewis | 0 36 | 0 6 | 0 1 | +220 -275 | FN Feb 5, 2023 | Submission | 1 | 3:47 |
| loss | Derrick Lewis | 4 15 | 0 0 | 0 0 | +130 -160 | UFC 277 Jul 30, 2022 | KO/TKO | 1 | :55 |
| loss | Derrick Lewis | 31 35 | 2 0 | 0 0 | -188 +150 | UFC 271 Feb 12, 2022 | KO/TKO | 2 | 3:53 |
| win | Derrick Lewis | 14 10 | 0 0 | 0 0 | +110 -140 | FN Dec 18, 2021 | KO/TKO | 1 | 2:12 |
| loss | Derrick Lewis | 16 112 | 0 0 | 0 0 | +250 -325 | UFC 265 Aug 7, 2021 | KO/TKO | 3 | 4:25 |
| win | Derrick Lewis | 7 28 | 0 0 | 0 0 | +300 -400 | FN Feb 20, 2021 | KO/TKO | 2 | 3:29 |
| win | Derrick Lewis | 35 3 | 1 1 | 0 2 | -200 +170 | UFC FIght Night Aug 8, 2020 | KO/TKO | 2 | :21 |
| win | Derrick Lewis | 27 62 | 0 3 | 0 0 | -240 +190 | UFC 247 Feb 8, 2020 | DEC | 3 | 1:27 |
| win | Derrick Lewis | | | | -111 -111 | UFC 244 Nov 2, 2019 | DEC | 3 | 5:00 |
| loss | Derrick Lewis Junior Dos Santos | 7 29 | 0 0 | 0 0 | +155 -200 | FN Mar 9, 2019 | KO/TKO | 2 | 1:58 |
| loss | Derrick Lewis Daniel Cormier | 5 42 | 0 4 | 0 1 | +450 -700 | UFC 230 Nov 3, 2018 | Submission | 2 | 2:14 |
| win | Derrick Lewis | 40 133 | 0 1 | 0 0 | +140 -170 | UFC 229 Oct 6, 2018 | KO/TKO | 3 | 4:49 |
| win | Derrick Lewis | 20 11 | 0 0 | 0 0 | +255 -335 | UFC 226 Jul 7, 2018 | DEC | 3 | 5:00 |
| win | Derrick Lewis | 32 83 | 1 1 | 0 1 | -110 -110 | FN Feb 18, 2018 | KO/TKO | 3 | 2:48 |
| loss | Derrick Lewis Mark Hunt | 52 59 | 0 0 | 0 0 | -170 +140 | FN Jun 10, 2017 | KO/TKO | 4 | 3:51 |
| win | Derrick Lewis Travis Browne | 39 23 | 0 0 | 0 0 | -123 +103 | FN Feb 19, 2017 | KO/TKO | 2 | 3:12 |
| win | Derrick Lewis | 46 77 | 1 4 | 0 1 | -240 +190 | FN Dec 9, 2016 | KO/TKO | 4 | 3:42 |
| win | Derrick Lewis Roy Nelson | 39 66 | 0 7 | 0 0 | +113 -133 | FN Jul 7, 2016 | DEC | 3 | 5:00 |
| win | Derrick Lewis Gabriel Gonzaga | 21 6 | 0 1 | 0 0 | -155 +125 | FN Apr 10, 2016 | KO/TKO | 1 | 4:48 |
| win | Derrick Lewis Damian Grabowski | 15 1 | 1 0 | 0 0 | -110 -110 | FN Feb 7, 2016 | KO/TKO | 1 | 2:17 |
| win | Derrick Lewis Viktor Pesta | 51 47 | 0 5 | 0 0 | +145 -170 | UFC 192 Oct 3, 2015 | KO/TKO | 3 | 1:15 |
| loss | Derrick Lewis Shawn Jordan | 8 65 | 0 3 | 0 0 | -103 -117 | FN Jun 6, 2015 | KO/TKO | 2 | :48 |
| win | Derrick Lewis Ruan Potts | 60 31 | 0 1 | 0 1 | -700 +525 | UFC 184 Mar 1, 2015 | KO/TKO | 2 | 3:18 |
| loss | Derrick Lewis Matt Mitrione | 1 9 | 0 0 | 0 0 | -130 +110 | FN Sep 5, 2014 | KO/TKO | 1 | :41 |
| win | Derrick Lewis Guto Inocente | 7 8 | 1 0 | 0 0 | -200 +160 | TUF 19 Jul 6, 2014 | KO/TKO | 1 | 3:30 |
| win | Derrick Lewis Jack May | 26 23 | 1 1 | 0 0 | -300 +250 | UFC on Fox Apr 19, 2014 | KO/TKO | 1 | 4:23 |
