Cardinals vs Bills Odds Odds & Picks - Week 1

The Arizona Cardinals visit the Buffalo Bills as 6.5-point road underdogs in Week 1 of the 2024 NFL season. With the total set at 48.5 football fans can expect Kyler Murray and Josh Allen to put on a show.

Check out all the Cardinals vs Bills odds and my best bets for Sunday's Highmark Stadium showdown.

Cardinals vs Bills Odds Week 1

Arizona Cardinals vs Buffalo Bills, Sept. 8, 1:00 pm ET

Team	Spread	Moneyline	Total
Arizona Cardinals	+6.5 (-110)	+245	Over 48.5 (-112)
Buffalo Bills	-6.5 (-110)	-300	Under 48.5 (-108)

Cardinals vs Bills Picks Week 1

Cardinals vs Bills UNDER 48.5 -108

Arizona projects to being a much better football team in 2024. The Cardinals have upgraded their offensive line by signing Jonah Williams, and if you haven't heard, they drafted Marvin Harrison Jr. in the first round.

Kyler Murray is now fully healthy and crucially, had a full off-season after being out with an ACL injury last year. This is the greatest collection of weapons and talent Murray has had around him in his NFL career. However, I think James Conner is the greatest equalizer in this game. He's been a wrecking ball when healthy, and Arizona should look to hand him the football early and often. Taking the air out of the football and grinding down the opposing defense has long been the strategy to defeating a top-tier NFL quarterback.

On the flip side, Buffalo has retooled after trading Stefon Diggs and losing Gabe Davis in free agency. This won't be the high-flying Bills offense of old, at least not right away. I expect there to be growing pains, as Josh Allen gets acquainted with his fresh, young receiving core. For those reasons, I really like the Cardinals vs Bills UNDER 48.5 points.

Cardinals vs Bills Prop Pick

Trey McBride OVER 49.5 Receiving Yards -114

Without Matt Milano patrolling the second-level of their defense, I'm not a big fan of Buffalo's ability to stop the pass. Especially across the middle of the field.

According the Next Gen Stats, the Bills allowed a success rate of over 70% when team's targeted the middle third without Milano in the lineup last season. Their pressure rate also dropped nearly 14% from over 37% to just 23% without their stalwart backer on the field in 2023.

McBride went ballistic last season once Kyler Murray returned, averaging 67.3 yards per game in eight contests. With an improved offensive line in front of Murray and Marvin Harrison Jr. out wide to draw attention away, bet on the Colorado State product to go haywire in Week 1.