Jared Goff and the Detroit Lions are 3.5-point road favorites as they visit the San Francisco 49ers in Week 17 Monday Night Football action. With two very capable offenses, oddsmakers set the total at 51.5.
This game isn't quite as exciting as it looked when the schedule first came out, as it's no longer a potential NFC Championship Game preview. The 49ers are out of the playoff race, but the Lions still have plenty to play for as they try to safeguard the No. 1 overall seed in the NFC and protect the NFC North Division lead.
Get ready for this NFL Week 17 Thursday Night Football showdown and check out all the Lions vs. 49ers and my favorite bets:
Lions vs 49ers Odds Week 17
Detroit Lions vs San Francisco 49ers, December 30th, 8:15 pm ET
| Team | Spread | Moneyline | Total |
| Detroit Lions | -3.5 (-110) | -185 | O 51.5 (-110) |
| San Francisco 49ers | +3.5 (-110) | +155 | U 51.5 (-110) |
Odds via Bet365 as of Dec. 23
Lions vs 49ers Week 17 Picks
Lions ML (-185)
I bet the Lions -2.5 before Week 16 games in our expert pick section, but now that the line has gone through the key number of 3, the moneyline is more appealing.
The Lions are playing really well right now, especially on offense, and it's tough to imagine them not destroying a 49ers defense that's been decimated with injuries. This is also a bit of a revenge spot for the Lions who lost in the NFC Championship game last season in particularly devastating fashion.
Lions quarteback Jared Goff has posted 17 touchdowns and 1 interception in his last six games and the 49ers secondary can be vulnerable to the deep ball.
Goff and company have to be excited to face a redzone defense that ranks 30th in the NFL while allowing opponents to score a touchdown in 65.31% of redzone trips. San Francisco's issues in the redzone are a big mismatch against Lions OC Ben Johnson who ranks 4th in the NFL in offensive redzone %.
As a cherry on top for Lions bettors, 49ers kicker Jake Moody continues to struggle and Kyle Shanahan is growing impatient with him in the media after previously supporting him publicly. Moody is 9-for-19 on kicks over 40 yards this year.
Lions vs 49ers Week 17 Props
Lions vs. 49ers NFL Week 17 Props aren't yet available at most sportsbooks. Be sure to check back as kickoff grows closer for my best player prop bet.
Lions vs 49ers News
San Francisco lost two keys players from its defense last week that may not be available for this contest. Linebacker Dre Greenlaw, who just made his season debut a couple weeks ago, went down with a calf injury and pass rusher Leonard Floyd had a shoulder injury. Keep an eye on the practice reports for the 49ers to see if Floyd and Greenlaw are trending toward playing.
Lions vs 49ers Week 17 Betting Trends
- San Francisco is 4-11 ATS in its last 15 games at home
- Detroit is 12-5 ATS in its last 17 games
- The total has gone OVER in 8 of Detroit's last 12 games
- Detroit is 12-1 SU in its last 13 games
- Detroit is 4-1 ATS in its last 5 games against San Francisco
- San Francisco is 1-6 ATS in its last 7 games
- San Francisco is 1-5 SU in its last 6 games
- The total has gone OVER in 4 of San Francisco's last 5 games against Detroit
