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Seahawks vs 49ers Odds & Picks Week 11: 49ers Offense Is Ready To Go Off

The San Francisco 49ers host the Seattle Seahawks as 6.5 point favorites in a Week 11 NFC West battle of two rivals trying to keep pace with the first place Arizona Cardinals. The total in this game is set at 48.5 after these times combined to score 50 points in Week 6.

Seattle should be well rested after its bye week and the 49ers enter this game feeling good about themselves after notching a 23-20 win vs. Tampa Bay in Christian McCaffrey's season debut. 

Keep reading to see how I'm approaching this game from a betting perspective. 

Seahawks vs 49ers Odds Week 11

Seattle Seahawks vs. San Francisco 49ers, Nov. 17, 4:05 pm ET

Seahawks vs 49ers Odds
TeamPoint SpreadMoneylineTotals
Seattle Seahawks +6.5 (-108)+240O 48.5 (-108)
San Francisco 49ers-6.5 (-112)-295U 48.5 (-112)

As of November 13 at FanDuel

Seahawks vs 49ers Picks Week 11

49ers TT O30.5 points (+144)

San Francisco put up 36 points in its last game vs. Seattle (Week 6) and that with without Ricky Pearsall, Christian McCaffrey and with Jordan Mason only getting nine carries. Sure, the 49ers had Brandon Aiyuk, but 2024 Aiyuk wasn't the same guy as last year and the 49ers offense is a lot sharper than it was in their first meeting.

Mason averaged 8.1 YPC (nine carries) vs. Seattle and Isaac Guerendo (10 carries) averaged 9.9 YPC. McCaffrey has to be licking his lips at this matchup and there might be a transition period after Seattle cut its leading tackler Tyrel Dodson earlier this week.

Brock Purdy sliced the Seahawks up in the last outing with three touchdowns and no interceptions on 255 yards. Mike Macdonald has a great scheme, but he just doesn't have the horses to stop a 49ers team with too much talent on the offensive side of the ball.

The 49ers are averaging 31.67 points per game in their last three contests vs. the Seahawks. 

Seahawks vs 49ers Prop Pick

It's a little too early in the week for a full compliment of player props for this game, so check back here to see my favorite option for the Seahawks vs. 49ers battle.

Seahawks vs 49ers News

DK Metcalf hasn't played since October 20th and Seahawks fans are hoping he'll be back for this one. Metcalf is expected to practice on Wednesday and coach Mike Macdonald said he's "optimistic" his stud wide receiver will suit up for this one.

Abe Lucas, Seattle's starting offensive tackle who hasn't played in about a year, might also play in this one. If so, backup offensive tackle George Fant might go on IR to clear room for him on the roster.

Seahawks' safety K'Von Wallace was placed on IR Monday after sustaining an injury in Seattle's prior game.

Seahawks vs 49ers Betting Trends

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  • Brock Purdy has gone over 16.5 rush yards in five straight games according to Outlier
  • Seattle is 1-5 SU & ATS in its last 6 games
  • Seattle is 1-5 ATS in its last 6 games against San Francisco
  • San Francisco is 4-9 ATS in its last 13 games
  • San Francisco is 4-2 SU in its last 6 games
  • San Francisco is 3-9 ATS in its last 12 games at home
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