2025 NFL Upsets Of The Week

NFL upsets haven't been fruitful this season, with favorites dominating proceedings. However, almost every week, the league serves up shockers as favorites fall, underdogs rise, and bankrolls swing in an instant. That's why tracking NFL upset picks should be at the top of your betting strategy with the 2025 NFL season underway. We've built his column to spotlight the most vulnerable favorites and underdogs primed to breakthrough each and every week.

From sneaky trap games to matchups where the line just doesn't add up, we'll break down chaos on the gridiron. Remember, NFL upsets are opportunities, and identifying the underdogs most likely to come through is one of the fastest ways to gain an edge on sportsbooks. Expect the 'dogs to be barking all year, and we'll be here to help you find the value.

Bookmark this page to stay locked in with our weekly NFL upset predictions all season long.

NFL Upsets of the Week Results So Far
Record	Unit Profit
11-19	-4.91

NFL Week 16 Upset Picks #1: Seattle Seahawks (-108) vs Los Angeles Rams

I'm backing the Seattle Seahawks as my first NFL upset pick of Week 16.

Davante Adams will miss this contest with a hamstring injury and Puka Nacua is banged up. The two receiver accounted for 76 yards and a touchdown in LA's earlier win over Seattle, in which the team mustered only 249 offensive yards. If Nacua is slowed heading into this quick Thursday Night Football turnaround, and the Seahawks can contain LA's rushing attack, they have a great shot at pulling off the upset. Devon Witherspoon gives the Seahawks a corner capable of slowing Nacua, and the Seahawks menacing pass-rush (5th in pass-rush win rate) gives them the ammo to defeat the top-seeded Rams.

Seattle is second in the NFL in EPA per play allowed over the last five weeks (-0.221) and lead the league in rushing success rate surrendered at only 32%. There are few ways to exploit Mike MacDonald's expertly coached defense. With the Rams weapons wounded, there's no better time for the Seahawks to capitalize. Plus, Sean McVay actually has a losing record when facing teams with winning percentages of 75% or higher. Back Seattle to pull off the upset in this monumental Week 16 clash.

NFL Week 16 Upset Picks #2: Tennessee titans (+160) vs Kansas City Chiefs

The deflating loss of all-world quarterback Patrick Mahomes is likely to linger into Week 16. Kansas City just isn't the same squad without their metronome under center. Without Mahomes' magic, the Chiefs woeful offense has little hope of making noise on Sunday. After all, Kansas City's scored just 23 points combined over the past two weeks, with Mahomes.

Now, Cam Ward and the Titans have some serious warts as a football team. However, Ward has a far more explosive arm than Chiefs backup Gardner Minshew, and he's not afraid to use it. Ward ripped a deep 34-yard hole-shot touchdown to fellow rookie Gunnar Helm last week, and looks more confident than ever in the pocket. Titans offensive coordinator Nick Holz will find the gaps in Steve Spagnuolo's blitzing scheme (how could he not, with a name like that). Plus, Tennessee has scored 24 or more points in three of the last four weeks. In a game with a total of just 37.5, backing the underdog is always a sharp play. Especially with a Titans team who have won two straight games as a home dog against the Chiefs. I like Tennessee to force the a rusty Minshew into multiple mistakes and pull off the upset as the home dog.