We're serving up the NFL upsets of Week 16 on a platter. The unpredictability of the NFL means that upsets are always on the horizon. In the wide world of NFL betting, analyzing which favored teams are most vulnerable to stumbling should be one of your first exercises each week. Thankfully, Odds Shark is here every week of the NFL season with our greatest NFL upsets of the week.
From under-the-radar matchups to potential shockers, dive into the key games where NFL underdogs could rise and favorites might fall. We live by and the upset and die by the upset in this column. And we're living good lately going 3-1 on our expert picks across the past two weeks. Buffalo came through for us in Detroit, while the Steelers couldn't get the job done in Philly. Let's dive into my NFL Week 16 upset picks.
NFL Week 16 Upset Pick #1: Denver Broncos (+198) @ Los Angeles Chargers
As I relayed in my Broncos vs Chargers Week 16 preview, Denver's defense will be the best unit on the field on Thursday Night Football.
The Broncos are the most efficient defense in the NFL over the past six weeks. They allow a league-leading 17.6 points per game and 0.270 points per play. While sitting second in opponent yards per play and red zone scoring percentage (42%).
With Ladd McConkey and Justin Herbert banged up and running back JK Dobbins on injured reserve, I don't see how the Chargers move the football. Expect to see the Broncos win a low-scoring defensive battle on Thursday night.
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NFL Week 16 Upset Pick #2: Jacksonville Jaguars (-104) @ Las Vegas Raiders
Listen, this isn't exactly the Bills vs Lions matchup from last week. Jaguars vs Raiders is an absolute dumpster fire that you couldn't pay me to watch. But, there is money to be made on backing the underdog Jaguars.
Las Vegas Raiders starting quarterback Desmond Ridder has averaged just 166 passing yards per game, with 16 total touchdowns and 14 interceptions in 18 career starts. He's taken 50 sacks, with a success rate of 44.5%. Ridder's coming off a brutal 23-of-39 for 208 yards, one touchdown, and two interception outing against his former team on MNF. The Jags defense is atrocious, but they should be able to rattle Ridder and win this football game.
Mac Jones is no Tom Brady, but he's proven capable of orchestrating an offense that boasts playmakers Travis Etienne and Tank Bigsby. They also employ the ever present threat of receiver Brian Thomas Jr. Jones played well enough to come threw as an underdog winner in Week 14 against the Titans, and we're betting Jacksonville can do it again in Vegas on Sunday.
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