The Kansas City Chiefs (4-2 SU, 2-4 ATS) are 0-5 SU and 1-4 ATS in five road games against the San Francisco 49ers (3-3, 3-3) since 1985. The Chiefs will try to snap this lengthy road losing streak in San Francisco by cashing in as a Chiefs vs 49ers prediction favorite this Sunday afternoon.
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- Date/Time: October 23, 4:25 p.m. ET
- Stadium: Levi’s Stadium
- TV Coverage: Fox
- Sportsbook Chiefs vs 49ers Odds: Chiefs -1.5 | O/U 47.5
- Chiefs vs 49ers Betting Matchup Report
Chiefs vs 49ers Sportsbook Odds
The Chiefs opened as 1.5-point road favorites before betting action on the road team drove the Chiefs vs 49ers odds in this matchup up to Kansas City -3. The total has also seen movement up to 48.5 points since Sportsbook at 47.5 points. The OVER is 6-1 in Kansas City’s last seven road games.
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- Best Spread-110-105KC-1+1SF
- Best Moneyline-115+106KCSF
- Best Total- --110Over49Under
Kansas City Fell Short At Home In Its Rematch Against Buffalo
Sunday’s Bills-Chiefs game lived up to its hype with the score tied at the end of the first three quarters and five lead changes throughout. In the end, the Bills came away with a hard-fought 24-20 road win, dropping Kansas City to 4-2 SU and 2-4 ATS on the season. Patrick Mahomes finished the day 25-for-40 with 338 yards, two passing touchdowns and two interceptions.
Travis Kelce was a big part of the offense as usual with eight catches for 108 receiving yards. But in a nice development for a Chiefs offense that has been looking for more production out of its wide receiver corps, JuJu Smith-Schuster was the team’s leading receiver with 113 yards and a touchdown on five catches.
San Francisco Couldn’t Overcome A Slow Start In Atlanta On Sunday
The 49ers entered their road game against the Atlanta Falcons last Sunday as 3.5-point road favorites in the midst of a 3-1 SU and ATS run. San Francisco’s defense was dominant over those four games, allowing only 260.5 total yards and 10.5 points per game. After falling into an early 14-0 hole in the first quarter, San Francisco went on to lose 28-14 to Atlanta, allowing 168 rushing yards in the loss.
The early deficit forced San Francisco out of its comfort zone on offense. Jimmy Garoppolo had to throw the ball 41 times, completing 29 of those passes for 296 yards, two touchdowns and two interceptions. The 49ers ran the ball just 16 times for 50 yards, a sharp dip from the 138.8 rushing yards per game that the team averaged through its first five games.
Chiefs: Keys To Victory
Kansas City is 0-3 SU and ATS in its last three games when scoring 24 points or less and 7-0 SU and 4-3 ATS when they’ve scored 25 points or more. The pressure will be on Patrick Mahomes and the Chiefs offense to crack through against this tough San Francisco defense to win as a Chiefs vs 49ers prediction.
49ers: Keys To Victory
San Francisco allowed two touchdowns (including one on a fumble return) in the first quarter last Sunday to dig a hole the team couldn’t climb out of. Preventing Kansas City from jumping out to an early lead and doing a better job of establishing the running game this week will be key to pulling off an upset as a Chiefs vs 49ers pick at home.
NFL Computer Pick: Chiefs -3.5
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- Kansas City is 5-1 ATS in its last 6 vs San Francisco.
- San Francisco is 6-0 ATS in its last 6 home games.
- The UNDER is 8-1 in San Francisco’s last 9 games.
